The CellBrief

In cell therapy manufacturing, no two processes are exactly alike. Each therapy has its own biology, workflow, and production challenges. For years, automation in this space meant choosing between flexibility and control – between innovation and standardization.

At CellBri, we believe you shouldn’t have to choose. That’s why our promise is simple:

Your Cell Therapy. Automated Your Way.

“Automated Your Way” means automation designed around your process, not the other way around. Legacy automation platforms in cell therapy come with rigid software, closed protocols, and restrictive licensing that force developers to conform. CellBri takes the opposite approach.

Our platforms – including both our modular and all-in-one solutions – combine the efficiency of fully automated, closed-system manufacturing with the freedom to configure, adapt, and evolve your workflows. From PBMC isolation and bead incubation, to transduction, expansion, wash, and final fill, every parameter can be customized – incubation times, feeding schedule, how many days you want your process to take, and more – all without compromising GMP compliance or process traceability.

This is automation designed to fit your science, your IP, and your long-term goals.

At the heart of CellBri’s innovation is flexible automation – a design philosophy that gives developers full control over their process while reducing manual touchpoints and variability.

Our modular systems deliver GMP-ready automation that can plug into existing autologous or large-scale allogeneic manufacturing processes and integrate with other instruments – meeting you where you are within your existing workflows. Users can define and adapt their own protocols, supported by features like continuous-flow centrifugation, multi-batch dispensing, and precision fill accuracy. We have worked with customers to customize over 100 protocols to perfectly fit their specific process conditions, ensuring scalability without rigidity.

Meanwhile, our all-in-one, CellFAB One Series pushes this adaptability further with models that can be tailored with different hardware combinations for non-magnetic sorting workflows, to dual micro- and nano- sized bead capture connecting to different cell expansion options. Developers can plug in for what they need today and expand capabilities as their programs evolve.

In short, flexibility isn’t an afterthought – it’s built into the architecture.

“Automated Your Way” also means freedom to operate. CellBri’s platforms are open by design with no locked software, no hidden licensing, no royalty restrictions.

Every workflow you develop is fully accessible, modifiable, and transferable. The system’s block-based interface allows intuitive optimization, while its open protocol structure means developers can freely integrate their own steps and materials. That freedom extends to scalability, with systems designed for lean clinical teams and compatible with GMP Grade C cleanrooms, reducing facility upkeep costs and training burdens.

CellBri’s approach to automation is grounded in real-world manufacturing challenges. From compliance to consistency, every feature is designed to help developers and manufacturers move faster and with greater confidence.

Because samples are precious, our quality-first engineering and rigorous testing framework ensure we deliver the performance and system reliability that the industry demands.  Single-use consumables and small tools minimize contamination risk and simplify transitions between batches. 21 CFR Part 11 compliance-readiness, secure audit trails, and robust user controls are essential in transitioning to GLP are part of the package from day one. And with integrated monitoring and real-time data logging, teams gain full process visibility without adding operational complexity.

Ultimately, “Automated Your Way” reflects a belief that automation should empower, not limit, innovation. It’s about giving every team, regardless of size, maturity or stage, the ability to design, test, and scale therapies on their own terms, while maintaining compliance and control.

At CellBri, our vision is to make cell therapies accessible to all by redefining how they’re made. With decades of experience in engineering, a solid IP foundation, and a customer-driven roadmap, our team continues to develop tools that help therapy developers reduce cost, streamline timelines, and minimize risk, without sacrificing flexibility or creativity.

Automation, after all, isn’t about replacing human ingenuity. It’s about amplifying it.

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